antibodies against serpine2 (R&D Systems)
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antibodies against serpine2
Antibodies Against Serpine2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+serpin+e2/Human+Serpin+E2%2FPN1+Antibody/pmc12085428-131-33-37
Average 93 stars, based on 3 article reviews
Antibodies Against Serpine2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+serpin+e2/Human+Serpin+E2%2FPN1+Antibody/pmc12085428-131-33-37
Average 93 stars, based on 3 article reviews
antibodies against serpine2 - by Bioz Stars,
2026-09
93/100 stars
Images
1) Product Images from "Elevated Serum SERPINE2 Levels are Linked to Impaired Renal Function in Patients with Type 2 Diabetes Mellitus"
Article Title: Elevated Serum SERPINE2 Levels are Linked to Impaired Renal Function in Patients with Type 2 Diabetes Mellitus
Journal: Diabetes Therapy
doi: 10.1007/s13300-025-01742-7
Figure Legend Snippet: Serum serpin peptidase inhibitor clade E member 2 (SERPINE2) levels were compared between control subjects and patients with type 2 diabetes mellitus (T2DM). a Serum SERPINE2 levels in control subjects and patients with T2DM were detected by enzyme-linked immunosorbent assay (ELISA). The serum SERPINE2 concentration in patients with T2DM ( n = 292) was significantly higher than that in control subjects ( n = 120). Student t test was applied. b Comparison of serum SERPINE2 levels in patients with T2DM with normoalbuminuria, microalbuminuria, and macroalbuminuria. ANOVA was applied. *** P < 0.001
Techniques Used: Control, Enzyme-linked Immunosorbent Assay, Concentration Assay, Comparison
Figure Legend Snippet: Correlation between serum serpin peptidase inhibitor clade E member 2 (SERPINE2) and clinical indicators. Pearson correlation test was performed between SERPINE2 with a estimated glomerular filtration rate (eGFR), b serum creatinine (Scr), c neutrophil gelatinase-associated lipocalin (NGAL), d kidney injury molecule 1 (KIM-1), e transforming growth factor-β1 (TGFβ1), and f connective tissue growth factor (CTGF) in all patients with type 2 diabetes mellitus (T2DM)
Techniques Used: Filtration
Figure Legend Snippet: Receiver operating characteristic (ROC) curve was used to obtain the optimal cutoff value of serum serpin peptidase inhibitor clade E member 2 (SERPINE2) (278.94 pg/mL) that distinguishes the patients with type 2 diabetes mellitus (T2DM) with and without albuminuria. AUC area under the curve
Techniques Used:
Figure Legend Snippet: Schematic diagram of serpin peptidase inhibitor clade E member 2 (SERPINE2) in the development of diabetic nephropathy. Increased SERPINE2 in patients with type 2 diabetes mellitus (T2DM) with renal dysfunction promotes podocyte injury and albuminuria. SERPINE2 also enhances renal fibrosis by promoting fibrosis-related cytokines, such as transforming growth factor-β1 (TGFβ1) and connective tissue growth factor (CTGF). Therefore, the increase in SERPINE2 levels plays an aggravating role in injury of glomerular and tubular cells caused by hyperglycemia and advanced glycation end products (AGEs)
Techniques Used:
Related Articles
Nucleic Acid Electrophoresis:Article Title: Functional autoantibodies against serpin E2 in rheumatoid arthritis. Article Snippet: .. Samples were suspended in Laemmli buffer, separated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis, and transferred to nitrocellulose membranes for immunodetection as previously described (29), using HRP-conjugated goat anti-human IgG antibodies (Jackson ImmunoResearch) or goat Immunodetection:Article Title: Functional autoantibodies against serpin E2 in rheumatoid arthritis. Article Snippet: .. Samples were suspended in Laemmli buffer, separated by sodium dodecyl sulfate–polyacrylamide gel electrophoresis, and transferred to nitrocellulose membranes for immunodetection as previously described (29), using HRP-conjugated goat anti-human IgG antibodies (Jackson ImmunoResearch) or goat |